News Center
- News Center：
- News Center>
- News Center>
- News Center>
- News Center
S-2238 | The Premier Choice for Thrombin-Specific Substrates
2025/2/11 16:00:37 Browse volume(41)Thrombin-Specific Substrate
S-2238
From Clinical Diagnosis to Research Applications，S-2238 has gained widespread recognition for its outstanding stability and sensitivity, whether used in clinical diagnostics or research experiments. Today, we will take an in-depth look at this high-performance thrombin substrate.
1.Product Properties
English Name：H-D-Phenylalanyl-L-pipecolyl-Larginine-p-nitroaniline
Another Name：S-2238
CAS Number：113711-77-6
Molecular Formula：H-D-Phe-Pip-Arg-pNA ? 2 HCl
Molecular Weight：625.55
Purity (HPLC)：> 99%
Absorption Coefficient：≤0.120 [L/(g·cm)]
Solubility：> 10 mg/mL in pure water
Storage Temperature：2-8℃
Packaging Specifications：25mg lyophilized powder (customizable in various quantities from mg to g levels)
Product Code：G04010237
2. Application Scenarios
Reagent Kit Production: Custom-designed for automated blood analyzers, enabling precise detection.
Antithrombin Diagnostics: Accurately measures antithrombin concentration in blood samples to diagnose antithrombin deficiency.
Heparin Monitoring: Monitors heparin concentration in blood throughout surgery to ensure safety.
Anticoagulant Activity Detection: Evaluates the anti-FXa and anti-FIIa activities of unfractionated heparin and low molecular weight heparin, providing scientific support for anticoagulation therapy.
Activity Assessment: Detects the anti-FIIa activity of chemically synthesized compounds or tissue extracts, aiding in drug development and substance screening.
3. Reaction Principle
S-2238 is a specific substrate for thrombin, with a structure designed to mimic the N-terminal region of the alpha chain of fibrinogen. Chemically modified to enhance stability and reactivity, it plays a critical role in detection. During testing, excess thrombin is added to the plasma sample, where antithrombin forms a 1:1 complex with thrombin. The remaining thrombin reacts with the chromogenic group p-nitroaniline of S-2238, producing coloration. The intensity of the color correlates positively with residual thrombin and negatively with antithrombin. By measuring absorbance changes through spectrophotometry, the activity can be precisely determined.
4. Unique Advantages of S-2238
High Specificity and Stability: Ensures accurate and reliable experimental results.
High Sensitivity: Capable of detecting minor changes in AT-III activity.
Simple and Fast Operation: Reduces experiment time and lowers operational complexity.
Wide Applications: Suitable for both research laboratories and clinical settings, supporting multiple scenarios including cardiovascular diseases, blood disorders, and monitoring the efficacy of anticoagulant drugs.
For more product information, please visit the Geneseqtools website: http://www.geneseqtools.com
Hotline: +86-133-0296-7066
Founded in 2015, the company focuses on the research, development, production, and sales of biochemical reagents for microbial detection, gene sequencing, and in vitro molecular diagnostics. We are committed to providing high-quality biochemical reagents and professional custom synthesis services. Our product range covers over a dozen categories with nearly a thousand innovative products. Adhering to the core values of "Customer First, Integrity, and Professionalism," we strive to meet the diverse needs of our clients in research and testing.
WeChat Office Account：Geneseqtools Biotech
Geneseqtools Website：http://www.geneseqtools.com
Consultation Hotline：+86-0755-36820717
QQ：2370561481
Email：sales@geneseqtools.com
Related Links
- · New release of GeneSeqTools Biotechnology Company Limited [2016-08-01]
- · New release of GeneSeqTools Biotechnology Company Limited [2024-05-20]
- · Co-creating a New Future in the Field of Microorganisms — The 19th Academic Symposium on Microbial Media Concludes Successfully [2024-12-02]
- · Conference Preview | Geneseqtools Biotechnology invites you to join the 19th Academic Symposium on Microbial Media [2024-11-11]
- · Recommended Series | 4-Methylumbelliferone — The Invisible Guardian in Daily Life [2024-12-06]
- · Recommended Series | Chromogenic Substrates for GBS Detection – Efficient Materials for Protecting Maternal and Infant Health [2024-12-12]
- · 【Exclusive】Recommended Series | Resorufin: The Fluorescent Probe Illuminating the Microscopic World [2024-12-13]
- · Recommended Series | Electrochemiluminescence Substrates: Innovative Materials Breaking Import Dependence [2025-01-06]
- · S-2238 | The Premier Choice for Thrombin-Specific Substrates [2025-02-11]
