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New In-Stock Product | MONNA (1572936-83-4): A Classic Inhibitor for Ca²⁺-Activated Chloride Channel Research

2026/5/8 15:20:46 Browse volume(8)
Small Molecule Compounds

MONNA (CAS: 1572936-83-4)


In cell function research, "how ions cross the cell membrane" often determines the direction of experimental results. Whether in TMEM16A functional validation, patch clamp electrophysiology experiments, or the study of Ca²⁺-activated chloride channel (CaCC) mechanisms, researchers need an answer to a key question: which specific ion channel is involved in the observed physiological response?

Especially in TMEM16A (ANO1)-related research, traditional CaCC inhibitors often suffer from insufficient selectivity and high background interference, making it difficult to accurately attribute experimental results and increasing the complexity of mechanism validation.

To address this need, GeneSeqTools Bioscience & Technology introduces MONNA (CAS: 1572936-83-4), a research-grade small molecule tool compound.

As a classic highly selective inhibitor of TMEM16A, MONNA can precisely block Ca²⁺-activated chloride channel (CaCC) activity, suitable for scenarios such as cellular membrane ion transport, electrophysiological analysis, and ion channel mechanism studies, helping researchers establish clearer and more reliable functional validation systems.

I. Product Overview

MONNA 1572936-83-4 Structural Formula

Chinese Name: 2-(4-Methoxynaphthalen-2-ylamino)-5-nitrobenzoic acid

English Name: 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

Abbreviation: MONNA

CAS Number: 1572936-83-4

Molecular Formula: C18H14N2O5

Molecular Weight: 338.32

Specifications: 10 mg / 100 mg / 1 g (Custom packaging supported)

Form: Solid powder

Product Number: G11010007

Stock: In stock


II. Working Principle

How does MONNA work? – “Calcium rises to open, MONNA locks the channel.”

Its mechanism can be summarized in one sentence: When a calcium signal triggers the opening of the ANO1 channel, MONNA immediately binds to key sites of the channel protein, inhibiting ANO1-mediated chloride conductance.

● Structure: In the anthranilic acid core of MONNA, the 5-position -NO₂ and the naphthalene 4′-OCH₃ constitute the key pharmacophore, enabling high-affinity recognition of the ANO1 channel protein conformation.
● Event: Increased intracellular Ca²⁺ concentration → Conformational change of ANO1 channel protein → Pore opening, enhanced transmembrane chloride transport. MONNA interacts with the ANO1 channel, significantly inhibiting Ca²⁺-activated chloride conductance.
● Signal: The original calcium-activated chloride current is suppressed, and the membrane potential tends toward hyperpolarization. In voltage-clamp or cell impedance sensing, changes in electrophysiological signals help assess the functional involvement of ANO1 in the target system.

III. Application Scenarios
● TMEM16A Functional Validation
Used to confirm whether TMEM16A is involved in the regulation of target cell functions, improving the accuracy of mechanistic studies.
● Electrophysiology Research
Suitable for CaCC blocking validation and ion current analysis in patch clamp and other experimental systems.
● Cellular Membrane Ion Transport Studies
Used to study Ca²⁺-dependent chloride transmembrane transport and changes in membrane electrical activity.
● Establishment of Ion Channel Screening Models
Applicable for the development of ANO1-related experimental models and channel regulation systems.

IV. Core Advantages

✅ Domestic In Stock
Independently supplied by GeneSeqTools, purity ≥98% (HPLC), eliminating import lead times and tariff premiums, offering more competitive pricing and faster shipping.

✅ High Selectivity
MONNA exhibits high inhibitory selectivity for TMEM16A/ANO1, helping to reduce experimental interference from other chloride channels.

✅ Low Background
Effective inhibition at low concentrations, minimizing the impact of non-specific effects on experimental results.

✅ Predictable
Indirect Ca²⁺ effects have been clearly reported; experimental designs can proactively set controls to avoid passive interpretation of off-target phenomena.



Extended Services

Domestic in stock, research-grade quality, a reliable partner for CaCC mechanism validation.

MONNA is in hot stock. Please call +86-13302967066!

GeneSeqTools Bioscience & Technology is dedicated to providing reliable domestic alternative solutions for gene sequencing, molecular diagnostics, and microbial detection.

For related products such as blood cell dyes and buffer salts, you can view the complete product line and technical specifications on [MedSun Biotechnology Website].


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